The 26-year-old was taken off during the first half of Spurs’ 4-1 Premier League defeat to Chelsea on Monday with an ankle injury, and his club have now confirmed he is unavailable for England’s Euro 2024 qualifiers at home to Malta on November 17 and away to North Macedonia on November 20.
Spurs said in a statement that the player would continue his rehabilitation at their Hotspur Way training center under the supervision of club medical staff.
Maddison had been included in the initial 25-man squad named by England manager Gareth Southgate on Thursday.
England sealed qualification for next summer’s Euros in Germany in their last qualifier, a 2-1 win over Italy at Wembley last month.